CORDIS Project
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This research focuses on developing new antimicrobials targeting specific components of bacterial membranes to combat antimicrobial resistance. It employs statistical design methods to accelerate the discovery of effective compounds that can enhance existing treatments.
Antimicrobial resistance in bacteria is a growing public health crisis, as common drugs are becoming ineffective against many species of pathogenic bacteria.
This research aims to devise highly specific and stable antimicrobials, which target the amphiphilic component that anchors LPS to Gram-negative bacterial membranes, “Lipid A”, for direct antimicrobial effect and to potentiate other antimicrobials.
Taking inspiration from bacterial lipids, which possess multiple tails and a polybasic headg…
UNIVERSITAET GRAZ
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