CORDIS Project
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This project investigates age-related macular degeneration, a leading cause of blindness. It focuses on the role of hypoxia-inducible factors in myeloid cells and aims to identify new therapeutic targets to improve treatment efficacy.
Age-related macular degeneration (AMD) is the commonest cause of blindness in the developed world. AMD is a progressive disorder of the outer retina characterised by the accumulation of extracellular deposits and chronic inflammation at the level of Bruch’s basement membrane.
Photoreceptor cell death is the result of progressive (‘geographic’) atrophy of supporting retinal pigment epithelium (RPE), or disruption by pathological neovascularisation that arises from the choroid and penetrates defec…
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