CORDIS Project
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This project investigates the interactions of amyloid peptides associated with Alzheimer's disease on neuronal membranes. Using advanced imaging techniques, it aims to elucidate the molecular mechanisms of toxicity and the potential synergistic effects of amyloid beta and Tau proteins, contributing to therapeutic strat…
The neuronal membrane is the target of specific molecular interactions involved in the development of Alzheimer’s disease (AD).
The 2 hallmarks of the disease, extracellular amyloid β plaques and intracellular Tau neurofibrillatory tangles, are inherently linked to the membrane, as this biointerface induces and influences amyloid fibrillation.
Moreover amyloid peptides selectively interact with the membrane depending of its composition, leading to toxicity mechanisms that are still poorly unders…
UNIVERSITE DE BORDEAUX
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