CORDIS Project
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This project investigates the effects of amyloid accumulation and dopamine function on cognitive abilities in healthy older adults. By utilizing advanced imaging techniques and neuropsychological assessments, it aims to clarify how these factors contribute to cognitive aging and the early stages of Alzheimer's disease.
Normal aging is associated with declines in episodic memory and executive functions.
Research suggests that around 20-50% of clinically healthy individuals show significant accumulation of amyloid, one of the hallmark biomarkers of Alzheimer’s disease but it has been difficult to establish the functional impact of amyloid burden in healthy older adults.
Decreases in dopaminergic functioning in old age have been shown to mediate age-related changes in various cognitive domains.
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