CORDIS Project
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This research aims to understand how amyloid fibrils, associated with misfolding diseases, interact with cell membranes and induce cell death. It will explore the mechanisms behind these interactions and their implications for cellular health.
Numerous pathological conditions, designated as misfolding diseases, involve conversion of specific proteins from their native, soluble state to highly ordered filamentous polymers.
For many years these amyloid fibrils were considered to be inert end-products of the aggregation pathway, while the toxic properties were mainly attributed to soluble oligomeric intermediates. A recent study demonstrated that fully assembled amyloid fibrils induce cell death, and the observed toxic effects are invers…
UNIVERSITY OF LEEDS
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