CORDIS Project
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This project investigates the molecular mechanisms behind protein aggregation into amyloid fibrils, focusing on the Acilphosphatase AcPDro2. By using advanced techniques like solution nuclear magnetic resonance and molecular simulations, it aims to uncover the atomic structure of aggregation intermediates and explore h…
Proteins and peptides have a generic tendency to convert from their soluble states into well-organized aggregates characterized by a fibrillar morphology and an extended cross-beta structure.
Such transitions can give rise to over 40 pathological conditions ranging from neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, polyQ disease, to systemic amyloidoses, including light chain amyloidosis and hemodyalisis-related amyloidosis.
Unveiling the origins of amyloid disor…
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