CORDIS Project
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This project investigates the effects of Extracorporeal Phototherapy (ECP) on dendritic cells and T cells in the context of graft versus host disease (GVHD) following stem cell transplantation. It aims to uncover the mechanisms behind ECP's immunoregulatory effects and identify new strategies for promoting tolerance in…
Allogeneic haematopoietic stem cell transplantation (HSCT) is an important curative therapy for a large number of hematological diseases.
Graft versus host disease (GVHD) remains the major complication of allogeneic HSCT, which occurs in 40-60% of transplant recipients and could be directly responsible for 25% of transplant related mortality and a significant proportion of transplant related morbidity.
Established immunosuppressive treatments are of limited efficacy and have significant side eff…
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