CORDIS Project
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This project focuses on developing new methods for asymmetric nucleophilic fluorination using peptide-based catalysts. By exploring the binding properties of a peptide library to fluoride, the project aims to create a novel catalytic process for synthesizing chiral fluorochemicals, which are important in pharmaceutical…
Asymmetric nucleophilic fluorination remains one of the most challenging transformations in organic chemistry.
In light of the importance of chiral fluorochemicals for the pharmaceutical sector, the development of innovative enantioselective fluorination methods with alkali metal fluoride is highly desirable.
In this work, we propose to merge two conceptual manifolds, namely peptide-based organocatalysis and hydrogen bonding phase-transfer catalysis.
We propose to investigate experimentally the…
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