CORDIS Project
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This project focuses on developing chimeric antigen receptor T cell therapies targeting tumor blood vessels to combat solid tumors. By utilizing a specific protein found in tumor endothelial cells, it aims to enhance treatment efficacy and reduce immune suppression in cancer therapy.
Advances of adoptive cellular therapy and monoclonal antibodies (mAbs) have resulted in unprecedented responses in patients with malignant tumors.
Due to the fact that tumor growth and metastasis depend on the formation of new blood vessels, termed angiogenesis, direct targeting of the tumor vasculature provides a universal point of engagement in the battle against cancer.
The main objective of this project is the development of chimeric antigen receptor (CAR) T cell approaches to target the tum…
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