CORDIS Project
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The ANTI-ATHERO project investigates the role of B cells in atherosclerosis, particularly in older individuals. It aims to identify age-related antigens for potential immunotherapy targets, linking immune response to cardiovascular disease progression.
Cardiovascular disease remains the leading cause of mortality worldwide, with atherosclerosis (AT) as the primary underlying factor.
Ageing is the strongest risk factor for both AT and CVD.
Emerging evidence indicates that the B cell-mediated immune response plays a pivotal role in the development and progression of AT, although the nature of this response and its triggering antigens are poorly understood.
In our prior research, we identified ALDH4A1 as novel AT antigen and showed that anti-ALDH…
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
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