CORDIS Project
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This project aims to discover new anti-CRISPR proteins that inhibit the CRISPR-Cas immune system in lactic acid bacteria. By employing high-throughput screening and advanced molecular techniques, it seeks to understand the mechanisms of these proteins and their implications for genetic engineering.
CRISPR-Cas immune system represents one of the most effective weapons against mobile genetic elements in the host defense arsenal.
Bacteriophages (phages) armed with anti-CRISPR proteins can, however, inhibit CRISPR immunity by sabotaging components of the immune system with evolutionary advantages.
This proposal sets out to discover novel phage-encoded anti-CRISPR proteins and understand the molecular mechanisms of the inhibitory processes.I will focus on novel anti-CRISPR proteins for Cas9-con…
TECHNISCHE UNIVERSITEIT DELFT
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