CORDIS Project
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This project investigates the interaction between CRISPR-Cas systems and anti-CRISPR genes in bacteria and their viruses. It aims to understand the ecological factors influencing the evolution of these genes and their coevolution through experimental co-culture studies.
CRISPR-Cas immune systems protect bacteria against their viruses (phage).
However, some phages encode anti-CRISPR (Acr) genes that block CRISPR-Cas activity.
While the molecular understanding of Acr activities and structures are racing ahead, their impact on the ecology and evolution of phage/bacteria populations remains unexplored.I first aim to identify the ecological factors that influence the selection for Acr genes, to explain why some phages encode many Acr whereas most encode none.
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