CORDIS Project
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This project investigates the human immune response to HIV-1 by identifying antiviral factors and their inducers. It aims to understand how these factors evolved and how they can be harnessed to develop new preventive and therapeutic strategies against viral infections.
Humans are equipped with a variety of intrinsic immunity or host restriction factors.
These evolved under positive selection pressure for diversification and represent a first line of defence against invading viruses.
Unfortunately, however, many pathogens have evolved effective antagonists against our defences.
For example, the capability of HIV-1 to counteract human restriction factors that interfere with reverse transcription, uncoating and virion release has been a prerequisite for the globa…
UNIVERSITAET ULM
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