CORDIS Project
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This project aims to develop a toolkit for targeting macromolecular interactions within cells, such as those between DNA and proteins or proteins themselves, using a new class of biostable peptide ligands. It focuses on creating libraries of these ligands and studying their structural properties and binding activities.
Nowadays, a multitude of examples for targeting enzymes with small molecules is known, whereas the direkt access to macromolecular interaction, such as DNA/protein, RNA/protein and protein/protein within the cell still waits to be solved by generic methods.
We intend to create a toolbox for targeting these interactions with D-/L-peptides, a new class of biostable oligomer ligands.
Initially we will establish split-and-pool libraries using postsynthetic dimerization of two orthogonal pairing part…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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