CORDIS Project
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This project aims to develop enzyme-degradable polymers for creating antimicrobial particle systems. By synthesizing responsive polymers and testing their effectiveness against specific bacteria, the research seeks to enhance the delivery of antimicrobial agents and address challenges in antimicrobial resistance.
Here, we will develop new enzyme-degradable polymers for the preparation of polyion complex (PIC) particles based of antimicrobial molecules with low charge densities.
The main goals are:1.
Synthesis of enzyme-responsive polymers, with a) enough charge density to facilitate PIC particle formation, and b) degradable by Pseudolysin, a protease secreted by opportunistic bacteria Pseudomonas aeruginosa;2.
Preparation of Pseudolysin-Degradable PIC Particles, from these enzyme responsive polymers and…
THE UNIVERSITY OF BIRMINGHAM
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