CORDIS Project
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This project investigates the mechanisms behind capillary permeability in critically ill patients, focusing on how inflammation affects vascular stability. By exploring a novel regulatory system, it aims to develop targeted therapies to prevent vascular leakage in conditions like sepsis.
Dysregulation of capillary permeability is a severe problem in critically ill patients, but the mechanisms involved are poorly understood.
Further, there are no targeted therapies to stabilize leaky vessels in various common, potentially fatal diseases, such as systemic inflammation and sepsis, which affect millions of people annually.
Although a multitude of signals that stimulate opening of endothelial cell-cell junctions leading to permeability have been characterized using cellular and in vi…
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