CORDIS Project
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The project aims to enhance the safety of umbilical cord-derived mesenchymal stem cells by silencing the tissue factor responsible for procoagulation activity. It utilizes innovative nanotechnology for effective delivery of small interfering RNA to prepare safer stem cells for potential therapeutic applications in vari…
Mesenchymal stem cells (MSC) isolated from the Wharton jelly of the umbilical cord (UC-MSC) show great potential for the use in allogeneic stem cell therapies for various human diseases.
However, the major limitation for the clinical use of allogeneic UC-MSC is their procoagulation activity, which is a consequence of expression of the tissue factor (TF), that can cause thromboembolism after transplantation, thus limiting their clinical usefulness.
Preparation of UC-MSC without the TF (UCMSC-TF-…
EDUCELL PODJETJE ZA CELICNO BIOLOGI JO DOO
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