CORDIS Project
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This project investigates the role of apolipoprotein E in the development of osteoarthritis linked to obesity. Using various methodologies, it aims to understand the molecular mechanisms behind obesity-induced osteoarthritis in mice and its implications for human health.
Osteoarthritis (OA) is the most common disease of the joints.
However, the molecular mechanisms that are involved in its pathogenesis are still unclear.
One of the major causes of OA is obesity.
The past few years a lot of studies have focused on the functional link between adipose tissue and cartilage in the development of OA.
It has been recently shown that apolipoprotein E (apoE) over-expression promotes diet-induced obesity in mice.
In addition, in vitro studies have demonstrated that apoE g…
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