CORDIS Project
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This project investigates the mechanisms of programmed cell death, focusing on the role of specific proteins in the mitochondrial membrane. By analyzing the structure and dynamics of these proteins, the research aims to enhance understanding of apoptosis and its implications for health and disease.
Apoptotic cell death is essential for development, immune function or tissue homeostasis, and it is often deregulated in disease.
Mitochondrial outer membrane permeabilization (MOMP) is central for apoptosis execution and plays a key role in its inflammatory outcome.
Knowing the architecture of the macromolecular machineries mediating MOMP is crucial for understanding their function and for the clinical use of apoptosis.Our recent work reveals that Bax and Bak dimers form distinct line, arc and…
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