CORDIS Project
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This project focuses on understanding the regulation of amyloid precursor protein levels in cells, which is crucial for Alzheimer’s disease. It aims to characterize the degradation pathway of this protein and its implications for neurodegeneration.
The pathological Ab peptide that accumulates in senile plaques in Alzheimer’s disease (AD) brains is derived from a precursor protein APP.
Although etiology of AD is complex, genetic evidence shows that duplication of the APP gene locus leading to elevated levels of APP protein is sufficient to cause early-onset AD highlighting the importance of regulatory mechanisms.
The events resulting in generation of Ab from APP are well characterized but the regulation of APP protein levels in cells is poo…
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