CORDIS Project
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The project focuses on improving the integration of foreign genes into the genomes of eukaryotic cells using a novel genetic switch. This technology enables faster and more reliable identification of stable transgene integration, facilitating advancements in genetic engineering across various applications.
Stable integration of exogenous transgenes in the genome of transfected eukaryotic host cells is essential in many biological, biotechnological and biomedical applications.
Naked DNA vectors are increasingly applied for this purpose as an alternative to viral particles due to their low cost, easy production and simplicity of use.
However, transgenesis with these vectors remains fundamentally hindered by the impossibility to distinguish integrated transgenes from those remaining in episomal form,…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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