CORDIS Project
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This project focuses on understanding the function of Arf-like proteins, particularly Arl2, Arl3, and Arl6, which are involved in ciliary diseases. By exploring their interactions and roles in cellular processes, it aims to clarify their contributions to ciliary function and related disorders.
Arl (Arf-like) proteins, GTP-binding proteins of the Ras superfamily, are molecular switches that cycle between a GDP-bound inactive and GTP-bound active state.
There are 16 members of the Arl subfamily in the human genome whose basic mechanistic function is unknown.
The interactome of Arl2/3 includes proteins involved in retinopathies and other ciliary diseases such as Leber¿s Congenital Amaurosis (LCA) and kidney diseases such as nephronophthisis.
Arl6 has been found mutated in Bardet Biedl Sy…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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