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The Arrachnobarrier2.0 project aims to investigate the arachnoid barrier's structure and function in the central nervous system. It seeks to understand its role in disease and its adaptations for cerebrospinal fluid transit, addressing a significant gap in neurobiology.
Less is known about the structural and functional importance of the arachnoid barrier than any other CNS barrier, including the blood-brain barrier.
Animal models of arachnoid barrier impairment are not known/have not been analyzed.
The sophisticated architecture and cellular specialization of the arachnoid barrier includes tight- and tricellular junctions joining two cell layers, direct contact with other arachnoid cells, and the specific expression of a broad repertoire of influx and efflux tr…
UPPSALA UNIVERSITET
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