CORDIS Project
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This project focuses on developing capsosomes, which are polymer capsules designed for oral delivery of an enzyme replacement therapy for phenylketonuria, a genetic disorder affecting amino acid metabolism. The aim is to enhance the stability and effectiveness of the enzyme during digestion to help manage phenylalanine…
Phenylketonuria (PKU) is the most common genetic enzyme defect, with an overall incidence in Europe and the USA of 1:10,000-20,000 live births per year.
Patients suffer from a genetic defect in the liver enzyme phenylalanine hydroxylase (PAH), which normally metabolizes the amino acid phenylalanine (Phe) into the amino acid tyrosine.
This specific enzyme defect, which results in an increase in the level of systemic Phe in the first few years of life, can lead to severe mental retardation.
Herein…
AARHUS UNIVERSITET
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