CORDIS Project
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This project focuses on understanding how alternative pre-mRNA splicing is regulated during transcription in human cells. It aims to uncover the mechanisms linking transcriptional processes and splicing, particularly through the phosphorylation of RNA polymerase II and chromatin modifications.
Alternative pre-mRNA splicing is more a rule than an exception because it is estimated to affect the expression of nearly 65%of human genes.
The importance of alternative splicing (AS) is confirmed by findings that mutations that affect it are frequent in human hereditary disease and because AS factors can be misregulated in cancer.
It is now well established that splicing can be cotranscriptional and that AS regulation not only depends on the interaction of splicing factors with their target se…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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