CORDIS Project
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This project explores the role of Atg8, a key regulator of autophagy, in cellular processes related to protein degradation. By investigating posttranslational modifications of Atg8, the research aims to uncover mechanisms that could lead to new treatments for diseases linked to autophagy dysregulation.
Autophagy is an important cellular degradation pathway required for eukaryotic protein homeostasis.
Deregulation of autophagy has been shown to cause the development of various human pathologies, including aggregation diseases and cancer.
Autophagy involves the formation of double-membrane vesicles, called autophagosomes, which sequester portions of the cytosol (general autophagy) or whole protein aggregates, organelles or pathogens (selective autophagy).
Autophagosomes then fuse with the lysoso…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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