CORDIS Project
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This project evaluates a new malaria treatment combining artemether-lumefantrine and atovaquone-proguanil in African children. A clinical trial will assess its safety and effectiveness compared to standard treatment, aiming to provide a robust solution against malaria, especially in light of rising drug resistance.
Susceptibility to Artemisinin-based combination therapies (ACTs) currently remains high among the African Plasmodium falciparum population, but resistant mutant has been detected recently.
To mitigate the risk of resistance leading to a dramatic increase in malaria related mortality, more efficient ACTs need to be urgently explored for quick deployment in Africa.
Artemether-lumefantrine (AL) is widely used and shows high efficacy and favourable safety in Africa but needs to be protected to incre…
BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN
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