CORDIS Project
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This project focuses on understanding the regulation of alternative splicing of pre-mRNAs, particularly in relation to cystic fibrosis. By studying RNA-protein interactions, the research aims to uncover the molecular basis of splicing errors and inform potential therapeutic strategies.
Alternative splicing of pre-mRNAs is tightly regulated and any imbalance can change the outcome of gene expression which often leads to disease.
Despite the importance of alternative splicing regulation our knowledge at the molecular level is still in its infancy hampering development of effective therapies.
We plan to study the regulatory RNA-protein and protein-protein interaction networks leading to skipping of CFTR exon 9 associated with severe forms of cystic fibrosis.
Structure determinati…
Masarykova univerzita
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