CORDIS Project
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This project investigates how genetic and metabolic pathways influence ageing at the molecular level, focusing on the role of sigma factors in individual E. coli cells. By utilizing microfluidic platforms and advanced imaging techniques, it aims to understand the stochastic dynamics of gene expression and their impact…
Ageing is controlled at the molecular level via genetic and metabolic pathways.
Ageing rates and patterns vary substantially even with fixed genetics and environment.
However, molecular mechanisms of ageing generating individual heterogeneity are poorly understood.
Stochastic dynamics of gene expression can be a main source of the variation in cellular damage dynamics leading to individual heterogeneity in ageing.
The sigma factor regulatory networks constitute the core part of the bacterial gen…
FREIE UNIVERSITAET BERLIN
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