CORDIS Project
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This project focuses on developing new synthetic methods for asperterpenoid, a compound with potential antitubercular properties. By exploring its synthesis and activity, the research aims to contribute to the fight against multi-drug resistant tuberculosis through innovative chemical strategies.
The rise of multi-drug resistant strains of Mycobacterium tuberculosis, the pathogen responsible for the infectious disease tuberculosis, calls for research into novel antitubercular scaffolds and targets.
Asperterpenoid is a rare sesterterpenoid with a unique and highly complex 5/7(3)/6/5 ring-fused carbon skeleton that strongly inhibits tyrosine phosphatase B, a virulence factor protein secreted by M. tuberculosis that aids human host infection.
To date, total synthesis of asperterpenoid has n…
AARHUS UNIVERSITET
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LOS ANGELES UCLA SANTA BARBARA UCSB DAVIS UCD RIVERSIDE UCR SAN DIEGO UCSD SANTA CRUZ UCSC IRVIN
United States, Berkeley
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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