CORDIS Project
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This project investigates a novel pathway for androgen synthesis in prostate cancer, focusing on how it contributes to the activation of the androgen receptor despite hormonal treatment. The goal is to identify new targets for inhibiting tumor growth in castration-resistant prostate cancer.
Prostate cancer (PC) is the most prevalent non-cutaneous cancer in men and leads to high morbidity and mortality.
Disseminated PC is treated by hormonal treatment in order to block intratumoral activation of the androgen receptor (AR) by 5α-dihydrotestosterone (DHT).
Despite this treatment, eventually all patients develop castration-resistant disease (CRPC) which is accompanied by poor prognosis.
Novel androgen synthesis and receptor inhibitors improve patient survival in CRPC, demonstrating the…
THE UNIVERSITY OF BIRMINGHAM
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