CORDIS Project
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This project investigates the mechanisms regulating centrosome positioning in cells by reconstituting actin and microtubule networks in a controlled environment. It aims to understand how centrosomes transition from the center to the periphery, which is crucial for cell differentiation.
The centrosome is one of the main microtubule-organizing centers in cells, spawning filaments that define the cells shape and polarity.
Peculiarly, it is almost always positioned either at the center of the cell or at its periphery, rarely in between.
Precise centrosome positioning is crucial: when positioned in the center, the centrosome has the fundamental task of integrating information from the whole cell via the microtubule network.
Instead, its swift transition to the periphery is a key st…
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