CORDIS Project
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This project investigates the role of ATG9 in the formation and expansion of autophagosomes, essential for cellular homeostasis. By utilizing advanced microscopy and molecular techniques, it aims to uncover the mechanisms behind autophagy regulation, which is crucial for understanding diseases like cancer and neurodege…
Autophagy is a conserved, lysosomal-mediated pathway required for cell homeostasis and survival.
It is controlled by the master regulators of energy (AMPK) and growth (TORC1) and mediated by the ATG (autophagy) proteins.
Deregulation of autophagy is implicated in cancer, immunity, infection, aging and neurodegeneration.
Autophagosomes form and expand using membranes from the secretory and endocytic pathways but how this occurs is not understood. ATG9, the only transmembrane ATG protein traffics…
THE FRANCIS CRICK INSTITUTE LIMITED
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