CORDIS Project
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This project explores the role of heme and heme-containing proteins in the oxidation of low-density lipoprotein (LDL), which contributes to atherosclerosis. It focuses on the mechanisms by which these proteins may influence cardiovascular disease development.
Atherosclerosis is the underlying process leading to the occurrence of cardiovascular diseases that accounts for one-third the world’s mortality.
Although multifactorial the pathogenesis of atherosclerosis is triggered to a large extent by elevated plasma cholesterol levels, and by the oxidation of low density lipoprotein (LDL).
The central hypothesis of this proposal is that proteins containing Fe protoporphyrin IX (heme) or free heme itself might act as central mechanism via which LDL is oxidi…
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