CORDIS Project
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This project investigates the structural mechanisms of autophagy, a cellular degradation process. By using advanced imaging techniques, it aims to understand how cells recognize and target specific materials for degradation, which is crucial for addressing various diseases.
Autophagy is a bulk cellular degradation pathway in which double-membrane vesicles engulfe large and long-lived cytoplasmic structures and target them to lysosomal compartments.
Employing an integrated structural biology approach using single-particle cryo-EM and X-ray crystallography, this proposal aims to elucidate the structural details by which the autophagosomal recognition machinery identifies and assembles its cargo for targeting to autophagosomes.
It has recently become apparent that sel…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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