CORDIS Project
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This project investigates the formation of autophagosomes, organelles involved in degrading cellular components, during the process of autophagy. It aims to clarify the mechanisms and factors involved in selective autophagy, using both yeast and human cell models.
I propose to study how eukaryotic cells generate autophagosomes, organelles bounded by a double membrane.
These are formed during autophagy and mediate the degradation of cytoplasmic substances within the lysosomal compartment.
Autophagy thereby protects the organism from pathological conditions such as neurodegeneration, cancer and infections.
Many core factors required for autophagosome formation have been identified but the order in which they act and their mode of action is still unclear.
We…
UNIVERSITAT WIEN
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