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The AVATAR project aims to transform personalized medicine by linking genetic variants to metabolic phenotypes through a computational modeling framework. It will analyze the interplay of genetics, diet, and microbiome to enhance the understanding of individual health and develop targeted treatments.
The increasing availability of whole-genome sequences will ultimately transform medicine into personalised medicine.
To realise this potential, we need to understand which of the millions of genetic variants in a person’s genome can alter a phenotype.
Genome-wide association studies (GWAS) have associated many genetic variants with thousands of phenotypic traits.
Metabolomics has further informed GWAS.
However, these methods do generally not consider the biochemical network connecting genetic va…
UNIVERSITY OF GALWAY
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