CORDIS Project
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This project investigates how endothelial cells behave in response to blood flow, focusing on their polarization and migration to form a functional vascular network. By using advanced imaging and genetic models, the research aims to uncover the mechanisms behind vascular patterning, which is crucial for understanding v…
The formation of a functional patterned vascular network is essential for development, tissue growth and organ physiology.
Several human vascular disorders arise from the mis-patterning of blood vessels, such as arteriovenous malformations, aneurysms and diabetic retinopathy.
Although blood flow is recognised as a stimulus for vascular patterning, very little is known about the molecular mechanisms that regulate endothelial cell behaviour in response to flow and promote vascular patterning.
Rece…
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
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