CORDIS Project
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This project investigates how endosomes in neurons regulate local protein synthesis, focusing on their role in axonal development and function. By using advanced imaging and genetic tools, it aims to uncover the mechanisms of mRNA translation and its implications for neuronal health.
Neurons are morphologically complex cells that rely on highly compartmentalized signaling to coordinate cellular functions.
The endocytic pathway is a crucial trafficking route by which neurons integrate, spatially process and transfer information.
Endosomal trafficking in axons and dendrites ensures that required molecules and signaling complexes are present where and when they are functionally needed thus fulfilling essential roles in neuronal physiology.
Our recent work has revealed the prese…
OSPEDALE SAN RAFFAELE SRL
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