CORDIS Project
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This research investigates how ribosomal proteins contribute to the maintenance and degeneration of axons in neurons. By studying local protein synthesis in axons, the project aims to uncover mechanisms that could inform treatments for neurodegenerative diseases.
Neurons make long-distance connections with synaptic targets via axons.
These axons survive throughout the lifetime of an organism, often many years in mammals, yet how axons are maintained is not fully understood.
Recently, we provided in vivo evidence that local mRNA translation in mature axons is required for their maintenance.
This new finding, along with in vitro work from other groups, indicates that promoting axonal protein synthesis is a key mechanism by which trophic factors act to prev…
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