CORDIS Project
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This project aims to develop a zebrafish model for studying neuroendocrine tumors, particularly focusing on resistance to anti-angiogenesis drugs. By engineering a transgenic model, it seeks to explore how these tumors respond to treatments and the mechanisms behind drug resistance.
Neuroendocrine tumours (NETs) consist of a range of rare neoplasms that may arise from any (neuro)endocrine cell situated in any part of the human body.
Despite the recent approval of two new drugs (sunitinib and everolimus) for pancreatic NETs, innate resistance is frequently encountered in these tumours and patients showing a response invariably relapse due to acquisition of resistance.
Moreover, while new data are being generated, including publication of the exome sequence of pancreatic neur…
THE UNIVERSITY OF MANCHESTER
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