CORDIS Project
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This project investigates the role of non-coding genetic variants in childhood cancers, specifically B-cell derived acute lymphoblastic leukemia. It focuses on the function of the ARID5B gene and its impact on B-cell development and leukemia progression using advanced CRISPR screening and mouse models.
While mutations at protein-coding sequences have been extensively characterized, the functional role of disease-associated non-coding variants remains largely elusive.
In fact, germline non-coding variants are often associated with increased risk of childhood cancers.
In B-cell derived acute lymphoblastic leukemia (B-ALL), the most common type of cancer in children, non-coding sequence variation at lineage-specific genes, such as IKZF1, GATA3 and CEBPE is associated with disease.
Interestingly,…
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CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH
Austria, Wien
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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