CORDIS Project
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This project investigates how parasitic infections influence the immune response, particularly focusing on B cells. By understanding these mechanisms, it aims to improve vaccine efficacy in individuals infected with helminths, addressing global health challenges.
One-fourth of the global population is currently infected with helminths, which modulate host immunity against not only their own antigens but also non-cognate antigens, including vaccines.
While antigen-specific antibodies and memory B cells are essential for protection against infectious diseases, how the B cell response quality is influenced by helminths remains largely unknown.
With my core expertise in studying responses to parasites at the level of single B cells and monoclonal antibodies,…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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