CORDIS Project
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The B3M project investigates the perivascular niche of cerebral blood vessels, focusing on the interaction between leukocytes and endothelial cells. It aims to recreate this environment using advanced materials and imaging techniques to better understand immune cell behavior and the role of the extracellular matrix in…
In neuroinflammation leukocytes reside for several days in the perivascular niche of cerebral blood vessels - defined by the basal surface of the endothelium, the endothelial basement membrane (BM) and an outer parenchymal BM with associated astrocyte endfeet (Fig. 1) - a poorly studied site but of utmost fundamental and clinical relevance.
This site is also emerging as harbouring genetically distinct resident cell populations, the function of which are unclear. BMs define the perivascular niche…
UNIVERSITAET MUENSTER
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