CORDIS Project
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This project explores bacterial adhesion to surfaces, aiming to develop engineered surfaces that enhance tissue adhesion while preventing pathogen attachment. By studying the interactions of oral pathogens with various materials, it seeks to improve medical implants and other applications.
Fundamental investigations of bacterial adhesion will create the knowledge base to advance surface engineering approaches.Directed mutagenesis of adhesin genes in several oral pathogens will be used to create a library of knockout strains.
Recombinant adhesins will also be over-expressed in E.coli.
Assays will be developed to test the interaction of the resulting strains (wild-type, knockouts, over-expressing E.coli clones) with a range of materials, covering the entire spectrum of surface prope…
UNIVERSITETET I OSLO
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