CORDIS Project
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This project investigates bacterial defense mechanisms against viruses, specifically focusing on abortive infection systems. By exploring genetic and environmental factors influencing these systems, the aim is to develop new antimicrobial strategies to combat bacterial infections.
The rise of antibiotic resistance demands new strategies to combat bacterial infections.
With renewed interest in phage-bacteria interactions, over 150 novel phage defence systems were recently identified, most of which protect bacteria from propagating phages via host-regulated death or growth arrest in an abortive infection process (Abi).
Abi systems, encoded primarily on mobile genetic elements, exhibit diverse mechanisms and are pervasive in bacteria.
However, despite significant mechanistic…
EBERHARD KARLS UNIVERSITAET TUEBINGEN
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