CORDIS Project
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This project investigates transcriptional gene silencing in plants, particularly how DNA methylation affects responses to bacterial infections. It aims to identify bacterial factors that interfere with this silencing mechanism using Arabidopsis thaliana as a model.
Transcriptional gene silencing (TGS) is an ancestral gene regulatory mechanism that operates at the level of chromatin and that involves various histone modifications as well as cytosine DNA methylation.
In both plants and animals, DNA methylation transcriptionally silences transposable elements (TEs), repeats, as well as some protein-coding genes that carry TEs/repeats in their vicinity.
Whereas DNA methylation has been extensively studied at particular stages of plants and animals development,…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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