CORDIS Project
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This project focuses on the mechanisms by which bacterial pathogens, such as Salmonella and Shigella, use specific proteins to invade host cells and evade immune responses. It aims to uncover the molecular interactions involved in this process to develop potential therapeutic inhibitors.
Bacterial pathogens have evolved distinct ways of colonizing host cells and promote infection.
Many human intestinal bacterial pathogens such as Salmonella, Shigella and enteropathogenic/ enterohemorrhagic Escherichia coli utilize type III secretion systems to deliver virulence effector proteins into the host to promote colonization and interfere with antimicrobial host response.
Among the type III effectors, the NleB protein has been shown to be essential for virulence of enteric pathogens.
Nle…
UNIVERSITY OF DUNDEE
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