CORDIS Project
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This research investigates how cells sense mechanical forces during embryonic development in fruit flies. It aims to identify the molecular mechanisms that convert mechanical signals into biochemical responses, focusing on the beta-catenin pathway during gastrulation.
During embryonic morphogenesis, cells do not only generate forces necessary for shape changes and tissue movement but also sense and respond to the forces exerted on them by neighbouring cells and tissues.
Recent studies demonstrate, that these forces can act as mechanical cues during development regulating cytoskeletal remodelling, cell proliferation and gene expression.
However, in most cases the molecular mechanism by which cells sense and transduce a mechanical signal into a biochemical sign…
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