CORDIS Project
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This project investigates the role of carbohydrate mimotope peptides in enhancing the function of specific B cell subpopulations as antigen presenting cells in cancer therapy. It aims to compare human and mouse B cells to develop effective immunotherapy strategies that leverage these cells for anti-tumor responses.
Our recent results on antitumor effects of carbohydrate mimotope peptides (CMP) suggest a possible role of carbohydrate reactive B cell subpopulations as cellular adjuvants.
As an abundant alternative of dendritic cells, CD40-activated B cells can efficiently present specific antigens being expandable for several weeks.
Some B cells can be sufficiently detrimental to warrant anti-B cell therapy in cancer.
Other (mouse) B cell subsets (e.g. B1 and marginal zone (MZ) B cells) seem as effective as…
THE STEPHAN ANGELOFF INSTITUTE OF MICROBIOLOGY, BULGARIAN ACADEMY OF SCIENCES
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